tert-Butyl 4-oxooctahydro-1H-indole-1-carboxylate
- Catalog NO.：A888164
- CAS No. : 1332584-12-9
- Molecular Formula：C13H21NO3
- Molecular Weight： 239.31
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Product Details
| CAS Number | 1332584-12-9 | Appearance | |
| Catalog Number | A888164 | MDL Number | MFCD24038873 |
| Molecular Formula | C13H21NO3 | Molecular Weight | 239.31 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | tert-Butyl 4-oxooctahydro-1H-indole-1-carboxylate | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
| GHS Pictogram |
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| Signal Word | Warning | UN Number | |
| Hazard Statements | H302-H317 | Class | |
| Precautionary Statements | P280-P305+P351+P338 | Packing Group | |
Description
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Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals.1 Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer.2,3,4,5,6 This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.7,8 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes |
