1-Hydroxybenzotriazole hydrate

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For R&D use only.

Catalog NO.：A805049
CAS No. : 123333-53-9
Molecular Formula：C₆H₅N₃O^.XH₂O
Molecular Weight： 153.13

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Product Details

CAS Number	123333-53-9	Appearance	White crystalline powder
Catalog Number	A805049	MDL Number	MFCD00065690
Molecular Formula	C₆H₅N₃O^.XH₂O	Molecular Weight	153.13
Boiling Point		Melting Point	155-160°C
Flash Point		Density
Synonyms	1-hydroxybenzotriazole hydrate;HOBT hydrate wetted with not less than 20 wt. % water
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	UN3474
Hazard Statements	H228	Class
Precautionary Statements	P210; P240; P241; P280; P370+P378	Packing Group	I

Description

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.

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H200	Explosives (Unstable Explosive)
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