5-Aminothiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione

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For R&D use only.

Catalog NO.：A876280
CAS No. : 30161-97-8
Molecular Formula：C₅H₄N₄O₂S
Molecular Weight： 184.18

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Product Details

CAS Number	30161-97-8	Appearance
Catalog Number	A876280	MDL Number	MFCD09839926
Molecular Formula	C₅H₄N₄O₂S	Molecular Weight	184.18
Boiling Point		Melting Point
Flash Point		Density
Synonyms	5-Aminothiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3259
Hazard Statements	H314	Class	8
Precautionary Statements	P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501	Packing Group	Ⅲ

Description

GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells.

1372540-25-4 (free base)

2108806-07-9 (HCl)

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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Store at temperatures not exceeding … oC/…oF. Keep cool.

P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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H300	Acute toxicity,oral (Category 1, 2)
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H302	Acute toxicity,oral (Category 4)
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H304	Aspiration hazard (Category 1)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
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H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
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H340	Germ cell mutagenicity (Category 1A, 1B)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
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