For R&D use only.

Monotropein

  • Catalog NO.:A869200
  • CAS No. : 5945-50-6
  • Molecular Formula:C16H22O11
  • Molecular Weight: 390.33
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Product Details

CAS Number 5945-50-6 Appearance
Catalog Number A869200 MDL Number MFCD00238650
Molecular Formula C16H22O11 Molecular Weight 390.33
Boiling Point 717.6oC at 760 mmHg Melting Point
Flash Point 262oC Density 1.73 g/cm3
Synonyms (1S,2S,6S,9R)-9-hydroxy-9-(hydroxymethyl)-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,7-diene-5-carboxylic acid
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H302-H315-H319-H335 Class
Precautionary Statements P301+P312+P330-P305+P351+P338 Packing Group

Description

High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.

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Monotropein
(1S,2S,6S,9R)-9-hydroxy-9-(hydroxymethyl)-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,7-diene-5-carboxylic acid