4-Fluoronitrobenzene

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For R&D use only.

Catalog NO.：A6148
CAS No. : 350-46-9
Molecular Formula：C₆H₄FNO₂
Molecular Weight： 141.1

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Product Details

CAS Number	350-46-9	Appearance
Catalog Number	A6148	MDL Number	MFCD00007282
Molecular Formula	C₆H₄FNO₂	Molecular Weight	141.1
Boiling Point	206.5°C at 760 mmHg	Melting Point	21-28°C
Flash Point		Density	1.33
Synonyms	1-Fluoro-4-nitro-benzene
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	UN2811
Hazard Statements	H302+H332-H311-H373	Class	6.1
Precautionary Statements	P280-P301+P310	Packing Group	III

Description

Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2 cellular activities. Potency of Nutlin-3b is much lower in the wild type p53 cells and has no effect regardless of the status of p53 cells.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
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H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
H360	Reproductive toxicity (Category 1A, 1B)
H361	Reproductive toxicity (Category 2)
H362	Reproductive toxicity, effects on or via lactation (Additional category)
H370	Specific target organ toxicity, single exposure (Category 1)
H371	Specific target organ toxicity, single exposure (Category 2)
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H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
H410	Hazardous to the aquatic environment, long-term hazard(Category 1)
H411	Hazardous to the aquatic environment, long-term hazard (Category 2)
H412	Hazardous to the aquatic environment, long-term hazard (Category 3)
H413	Hazardous to the aquatic environment, long-term hazard (Category 4)
H420	Hazardous to the ozone layer (Category 1)