(5E)-5-[ethoxy(hydroxy)methylidene]-2-methyl-1,3-thiazol-4-one

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For R&D use only.

Catalog NO.：A814849
CAS No. : 20737-48-8
Molecular Formula：C₇H₉NO₃S
Molecular Weight： 187.22

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Product Details

CAS Number	20737-48-8	Appearance	Light yellow solid
Catalog Number	A814849	MDL Number	MFCD08275722
Molecular Formula	C₇H₉NO₃S	Molecular Weight	187.22
Boiling Point	270.7°C at 760 mmHg	Melting Point
Flash Point	117.5°C	Density	1.325g/cm3
Synonyms	(5E)-5-[ethoxy(hydroxy)methylidene]-2-methyl-1,3-thiazol-4-one
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H319	Class
Precautionary Statements	P305+P351+P338	Packing Group

Description

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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