XL-147
- Catalog NO.:A859771
- CAS No. : 934526-89-3
- Molecular Formula:C25H25ClN6O4S
- Molecular Weight: 541.02
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Product Details
CAS Number | 934526-89-3 | Appearance | Solid |
Catalog Number | A859771 | MDL Number | MFCD26142605 |
Molecular Formula | C25H25ClN6O4S | Molecular Weight | 541.02 |
Boiling Point | 638.9°C at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor, and is a n orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. |