SB-366791

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For R&D use only.

Catalog NO.：A900888
CAS No. : 472981-92-3
Molecular Formula：C₁₆H₁₄ClNO₂
Molecular Weight： 287.74

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Product Details

CAS Number	472981-92-3	Appearance
Catalog Number	A900888	MDL Number	MFCD01033818
Molecular Formula	C₁₆H₁₄ClNO₂	Molecular Weight	287.74
Boiling Point	494.2°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

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GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM
target: VR1/TRPV1
IC 50: 5.7±1.2 nM [1]
SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2]

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H200	Explosives (Unstable Explosive)
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H318	Serious eye damage/eye irritation (Category 1)
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