1-(Tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid

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For R&D use only.

Catalog NO.：A860232
CAS No. : 917835-93-9
Molecular Formula：C₁₁H₁₉NO₅
Molecular Weight： 245.27

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	917835-93-9	Appearance	White powder
Catalog Number	A860232	MDL Number	MFCD06410967
Molecular Formula	C₁₁H₁₉NO₅	Molecular Weight	245.27
Boiling Point	404.1±45.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	1-(Tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors. Ponatinib was approved in 2012.

943319-70-8 (free base)

1114544-31-8 (HCl)

1232836-25-7 (tris-hydrochloride)

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P301	IF SWALLOWED:
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire: Use … for extinction.
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