(3-Methoxypropyl)trimethoxysilane

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For R&D use only.

Catalog NO.：A875242
CAS No. : 33580-59-5
Molecular Formula：C₇H₁₈O₄Si
Molecular Weight： 194.30

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Product Details

CAS Number	33580-59-5	Appearance
Catalog Number	A875242	MDL Number	MFCD00054721
Molecular Formula	C₇H₁₈O₄Si	Molecular Weight	194.30
Boiling Point	168.1°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	Trimethoxy(3-methoxypropyl)silane
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	1993
Hazard Statements	H226-H315-H319-H335	Class	3
Precautionary Statements	P261-P305+P351+P338	Packing Group	Ⅲ

Description

Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

183319-69-9 (HCl)

183321-74-6 (free base)

248594-19-6 (mesylaye)

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
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H340	Germ cell mutagenicity (Category 1A, 1B)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
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