1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde
- Catalog NO.:A837627
- CAS No. : 728034-12-6
- Molecular Formula:C8H6N2O
- Molecular Weight: 146.15
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Product Details
CAS Number | 728034-12-6 | Appearance | Yellow powder |
Catalog Number | A837627 | MDL Number | MFCD08272237 |
Molecular Formula | C8H6N2O | Molecular Weight | 146.15 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Cyclopamine, also known as 11-deoxojervine, is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho. |