8-Hydroxyquinoline-5-sulfonic acid

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For R&D use only.

Catalog NO.：A840972
CAS No. : 84-88-8
Molecular Formula：C₉H₇NO₄S
Molecular Weight： 225.22

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Product Details

CAS Number	84-88-8	Appearance
Catalog Number	A840972	MDL Number	MFCD00006795
Molecular Formula	C₉H₇NO₄S	Molecular Weight	225.22
Boiling Point		Melting Point
Flash Point		Density
Synonyms	8-Hydroxyquinoline-5-sulfonic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	2811
Hazard Statements	H290-H302-H314-H332-H341	Class	6.1
Precautionary Statements	P201-P260-P280-P305+P351+P338-P310	Packing Group	Ⅲ

Description

A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is substantially more potent against BCL-XL-dependent cell lines relative to WEHI-539, while possessing none of its inherent pharmaceutical liabilities. A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. A-1155463 thus represents an excellent tool molecule for studying BCL-XL biology as well as a productive lead structure for further optimization.

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P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
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H311	Acute toxicity,dermal (Category 3)
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H314	Skin corrosion/irritation (Category 1A, B, C)
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H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
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H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
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H371	Specific target organ toxicity, single exposure (Category 2)
H372	Specific target organ toxicity, repeated exposure (Category 1)
H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
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