ISRIB (trans-isomer)

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For R&D use only.

Catalog NO.：A899328
CAS No. : 1597403-47-8
Molecular Formula：C₂₂H₂₄Cl₂N₂O₄
Molecular Weight： 451.34

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1597403-47-8	Appearance	White powder
Catalog Number	A899328	MDL Number	MFCD27952932
Molecular Formula	C₂₂H₂₄Cl₂N₂O₄	Molecular Weight	451.34
Boiling Point	719.0±60.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

1231929-97-7 (free base)

1231930-82-7 (mesylate)

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