2-Chloro-4,6-diphenyl-1,3,5-triazine

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For R&D use only.

Catalog NO.：A824145
CAS No. : 3842-55-5
Molecular Formula：C₁₅H₁₀ClN₃
Molecular Weight： 267.71

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Product Details

CAS Number	3842-55-5	Appearance
Catalog Number	A824145	MDL Number	MFCD05738885
Molecular Formula	C₁₅H₁₀ClN₃	Molecular Weight	267.71
Boiling Point		Melting Point	135-142°C
Flash Point		Density
Synonyms	2-chloro-4,6-diphenyl-1,3,5-triazine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	Not hazmat
Hazard Statements	H315; H319; H335	Class
Precautionary Statements	P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501	Packing Group

Description

GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells.

1372540-25-4 (free base)

2108806-07-9 (HCl)

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H200	Explosives (Unstable Explosive)
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H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
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H304	Aspiration hazard (Category 1)
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