TG101209
- Catalog NO.:A19414
- CAS No. : 936091-14-4
- Molecular Formula:C26H35N7O2S
- Molecular Weight: 509.67
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Product Details
CAS Number | 936091-14-4 | Appearance | |
Catalog Number | A19414 | MDL Number | MFCD15528085 |
Molecular Formula | C26H35N7O2S | Molecular Weight | 509.67 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide;TG 101209 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
TG101209 is a novel and potent JAK2 inhibitor, which induced dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209 , when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. |