2-Oxa-5-azabicyclo[4.1.0]heptane hydrochloride
- Catalog NO.:A887012
- CAS No. : 1354952-28-5
- Molecular Formula:C5H10ClNO
- Molecular Weight: 135.59
Note*
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 1354952-28-5 | Appearance | |
Catalog Number | A887012 | MDL Number | MFCD20441759 |
Molecular Formula | C5H10ClNO | Molecular Weight | 135.59 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 2-Oxa-5-azabicyclo[4.1.0]heptane hydrochloride | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group |
Description
A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is substantially more potent against BCL-XL-dependent cell lines relative to WEHI-539, while possessing none of its inherent pharmaceutical liabilities. A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. A-1155463 thus represents an excellent tool molecule for studying BCL-XL biology as well as a productive lead structure for further optimization. |