NPOC-POC Tenofovir Fumarate

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For R&D use only.

Catalog NO.：A891463
CAS No. : 1217542-13-6
Molecular Formula：C₂₃H₃₄N₅O₁₄P
Molecular Weight： 635.52

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Product Details

CAS Number	1217542-13-6	Appearance
Catalog Number	A891463	MDL Number
Molecular Formula	C₂₃H₃₄N₅O₁₄P	Molecular Weight	635.52
Boiling Point	647.5±65.0 °C(Predicted)	Melting Point
Flash Point		Density	1.45±0.1 g/cm3 (20 oC 760 Torr)
Synonyms	[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propyl carbonate
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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