4-(2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)benzene-1,2-diol hydrochloride

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For R&D use only.

Catalog NO.：A827836
CAS No. : 49745-95-1
Molecular Formula：C₁₈H₂₄ClNO₃
Molecular Weight： 337.84

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	49745-95-1	Appearance	Off-white powder
Catalog Number	A827836	MDL Number	MFCD13185823
Molecular Formula	C₁₈H₂₄ClNO₃	Molecular Weight	337.84
Boiling Point	263.8°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	4-[2-[[3-(4-hydroxyphenyl)-1-methyl-propyl]amino]ethyl]benzene-1,2-diol hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Cabozantinib, also known as XL-184 or BMS-907351, is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. Cabozantinib was approved by the U.S. FDA in November 2012 for the treatment of medullary thyroid cancer.

1140909-48-3(malate)

849217-68-1(free base)

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