2,2'-Azobis-1H-benzimidazole

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For R&D use only.

Catalog NO.：A905657
CAS No. : 15507-27-4
Molecular Formula：C₁₄H₁₀N₆
Molecular Weight： 262.28

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Product Details

CAS Number	15507-27-4	Appearance
Catalog Number	A905657	MDL Number
Molecular Formula	C₁₄H₁₀N₆	Molecular Weight	262.28
Boiling Point		Melting Point
Flash Point		Density
Synonyms	1H-Benzimidazole,2,2'-azobis- (9CI)
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.

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