SAR407899 hydrochloride

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For R&D use only.

Catalog NO.：A860114
CAS No. : 923262-96-8
Molecular Formula：C₁₄H₁₇ClN₂O₂
Molecular Weight： 280.75

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	923262-96-8	Appearance	Off-white to light yellow powder
Catalog Number	A860114	MDL Number	MFCD20485429
Molecular Formula	C₁₄H₁₇ClN₂O₂	Molecular Weight	280.75
Boiling Point		Melting Point
Flash Point		Density
Synonyms	6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302;H315;H319;H335	Class
Precautionary Statements	P261;P305+P351+P338	Packing Group

Description

SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632.

923262-96-8 (HCl)

923359-38-0 (free base)

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