4,4-Methylenebis(N,N-bis(oxiran-2-ylmethyl)aniline)

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For R&D use only.

Catalog NO.：A876633
CAS No. : 28768-32-3
Molecular Formula：C₂₅H₃₀N₂O₄
Molecular Weight： 422.52

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Product Details

CAS Number	28768-32-3	Appearance
Catalog Number	A876633	MDL Number	MFCD00661161
Molecular Formula	C₂₅H₃₀N₂O₄	Molecular Weight	422.52
Boiling Point	619.3°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	4,4-Methylenebis(N,N-bis(oxiran-2-ylmethyl)aniline)
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3082
Hazard Statements	H317-H341-H411	Class	9
Precautionary Statements	P280	Packing Group	Ⅲ

Description

Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

183319-69-9 (HCl)

183321-74-6 (free base)

248594-19-6 (mesylaye)

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H200	Explosives (Unstable Explosive)
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