MELK-T1

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For R&D use only.

Catalog NO.：A903708
CAS No. : 1610586-62-3
Molecular Formula：C₂₁H₂₂N₄O₂
Molecular Weight： 362.43

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Product Details

CAS Number	1610586-62-3	Appearance
Catalog Number	A903708	MDL Number
Molecular Formula	C₂₁H₂₂N₄O₂	Molecular Weight	362.43
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)benzamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells. MELK-T1 triggered a rapid and proteasome-dependent degradation of the MELK protein. Treatment of MCF-7 breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. MELK-T1 induced a strong phosphorylation of p53, a prolonged upregulation of p21 and a downregulation of FOXM1 target genes.

1610536-69-0 (HCl)

1610586-62-3 (free base)

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