3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one

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For R&D use only.

Catalog NO.：A812370
CAS No. : 178445-83-5
Molecular Formula：C₁₇H₁₈O₄
Molecular Weight： 286.32

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Product Details

CAS Number	178445-83-5	Appearance	Off-white powder
Catalog Number	A812370	MDL Number	MFCD06245367
Molecular Formula	C₁₇H₁₈O₄	Molecular Weight	286.32
Boiling Point	479.1°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)propan-1-one
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501	Packing Group

Description

(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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