4,5-Dichloro-2-fluorobenzoic acid
- Catalog NO.:A20282
- CAS No. : 289039-49-2
- Molecular Formula:C7H3Cl2FO2
- Molecular Weight: 209.00
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Product Details
CAS Number | 289039-49-2 | Appearance | |
Catalog Number | A20282 | MDL Number | MFCD00672988 |
Molecular Formula | C7H3Cl2FO2 | Molecular Weight | 209.00 |
Boiling Point | 304.6℃ at 760 mmHg | Melting Point | |
Flash Point | Density | ||
Synonyms | 4,5-Dichloro-2-fluoro-benzoic acid | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H332-H335 | Class | |
Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group |
Description
BMS-708163 (avagacestat) is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. Avagacestat produced up to 190-fold greater selectivity for Aβ synthesis than Notch processing in preclinical studies and may therefore produce less toxic adverse events than other less selective compounds. Results from this single-ascending dose study suggest that avagacestat was tolerated at a single-dose range of 0.3 to 800 mg and suitable for further clinical development. |