Bis(10-hydroxybenzo[h]quinolinato)beryllium

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Catalog NO.：A847604
CAS No. : 148896-39-3
Molecular Formula：C₂₆H₁₆BeN₂O₂
Molecular Weight： 397.43

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Product Details

CAS Number	148896-39-3	Appearance
Catalog Number	A847604	MDL Number	Not available
Molecular Formula	C₂₆H₁₆BeN₂O₂	Molecular Weight	397.43
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Benzo[h]quinolin-10-ol, beryllium salt (2:1)
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Sunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus results in tumor shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors.

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