CYC065
- Catalog NO.:A903453
- CAS No. : 1070790-89-4
- Molecular Formula:C21H31N7O
- Molecular Weight: 397.53
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Product Details
CAS Number | 1070790-89-4 | Appearance | |
Catalog Number | A903453 | MDL Number | |
Molecular Formula | C21H31N7O | Molecular Weight | 397.53 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (2R,3S)-3-((6-(((4,6-Dimethylpyridin-3-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)pentan-2-ol | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
CYC065 is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities. CYC065 selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow. 1070790-89-4 (free base) 1315571-38-0 (HCl) |