For R&D use only.

2-Chloro-4-(trifluoromethyl)pyridine

  • Catalog NO.:A9998
  • CAS No. : 81565-18-6
  • Molecular Formula:C6H3ClF3N
  • Molecular Weight: 181.54
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 81565-18-6 Appearance Colorless Liquid
Catalog Number A9998 MDL Number MFCD00042224
Molecular Formula C6H3ClF3N Molecular Weight 181.54
Boiling Point 146-147 °C(lit.) Melting Point -19°C
Flash Point 127 °F Density
Synonyms 2-Chloro-4-(trifluoromethyl)pyridine
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

1231929-97-7 (free base)

1231930-82-7 (mesylate)

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2-Chloro-4-(trifluoromethyl)pyridine
2-Chloro-4-(trifluoromethyl)pyridine