XMD8-92

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For R&D use only.

Catalog NO.：A899024
CAS No. : 1234480-50-2
Molecular Formula：C₂₆H₃₀N₆O₃
Molecular Weight： 474.56

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1234480-50-2	Appearance	Light yellow powder
Catalog Number	A899024	MDL Number	MFCD18782742
Molecular Formula	C₂₆H₃₀N₆O₃	Molecular Weight	474.56
Boiling Point		Melting Point
Flash Point		Density
Synonyms	2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

XMD8-92 is a BMK1 inhibitor and a highly selective inhibitor of ERK5 activity. XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. XMD8-92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals.

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H200	Explosives (Unstable Explosive)
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H300	Acute toxicity,oral (Category 1, 2)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
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H420	Hazardous to the ozone layer (Category 1)