Ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate

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Catalog NO.：A905865
CAS No. : 5606-55-3
Molecular Formula：C₁₈H₁₅ClN₂O₃
Molecular Weight： 342.78

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Product Details

CAS Number	5606-55-3	Appearance
Catalog Number	A905865	MDL Number
Molecular Formula	C₁₈H₁₅ClN₂O₃	Molecular Weight	342.78
Boiling Point		Melting Point
Flash Point		Density
Synonyms	Ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

698387-09-6 (free base)

915942-22-2 (maleate)

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