Debio-0932
- Catalog NO.:A903378
- CAS No. : 1061318-81-7
- Molecular Formula:C22H30N6O2S
- Molecular Weight: 442.58
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Product Details
CAS Number | 1061318-81-7 | Appearance | |
Catalog Number | A903378 | MDL Number | |
Molecular Formula | C22H30N6O2S | Molecular Weight | 442.58 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | CUDC305; CUDC-305;2-((6-(dimethylamino)benzo[d][1,3]dioxol-5-yl)thio)-1-(2-(neopentylamino)ethyl)-1H-imidazo[4,5-c]pyridin-4-amine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | Class | ||
Precautionary Statements | Packing Group |
Description
Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. |