7-Azaindole-5-carboxylic acid
- Catalog NO.：A22618
- CAS No. : 754214-42-1
- Molecular Formula：C8H6N2O2
- Molecular Weight： 162.15
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Product Details
| CAS Number | 754214-42-1 | Appearance | |
| Catalog Number | A22618 | MDL Number | MFCD08272240 |
| Molecular Formula | C8H6N2O2 | Molecular Weight | 162.15 |
| Boiling Point | Melting Point | ||
| Flash Point | Density | ||
| Synonyms | 1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid | ||
| Storage Condition | Store in a tightly closed container,in a cool and dry place | ||
Safety
| GHS Pictogram |
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| Signal Word | Warning | UN Number | |
| Hazard Statements | H302-H315-H319-H332-H335 | Class | |
| Precautionary Statements | P261-P280-P305+P351+P338 | Packing Group | |
Description
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AMD11070, also known as AMD070, X4P-001 and mavorixafor, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. |
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- A901217
- 83314-01-6
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