Dextromethorphan hydrobromide monohydrate

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For R&D use only.

Catalog NO.：A854646
CAS No. : 6700-34-1
Molecular Formula：C₁₈H₂₈BrNO₂
Molecular Weight： 370.32

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	6700-34-1	Appearance	White powder
Catalog Number	A854646	MDL Number
Molecular Formula	C₁₈H₂₈BrNO₂	Molecular Weight	370.32
Boiling Point	486.1oC at 760 mmHg	Melting Point	116-119°C
Flash Point		Density
Synonyms	(4bS,8aS,9S)-3-methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene hydrobromide hydrate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	2811
Hazard Statements	H301;H411	Class	6.1
Precautionary Statements	P264;P270;P273;P301+P310+P330;P391;P405;P501	Packing Group	III

Description

ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM). Displays selectivity for mTOR over other PI 3K family kinases (IC50 values are 0.102, 0.408, 1.27, 1.96 and 2.2 μM for p110γ, DNA-PK, p110δ, p110α and p110β respectively) and 215 further kinases. Displays modest inhibition of PKCα, JAK2, PKCβI, PKCβII and RET (IC50 values are 0.049, 0.110, 0.185, 0.198 and 0.224 μM respectively). Inhibits both S6K and 4EBP1 phosphorylation; activity causes a decrease in cap-dependent protein translation. Also triggers downregulation of cFLIPS and augments TRAIL-induced apoptosis of cancer cells.

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