MDK36057
- Catalog NO.:A902839
- CAS No. : 950736-05-7
- Molecular Formula:C29H24F3N5O
- Molecular Weight: 515.53
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Bulk Inquiry
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Quality Control&SDS
Product Details
CAS Number | 950736-05-7 | Appearance | |
Catalog Number | A902839 | MDL Number | MFCD25977055 |
Molecular Formula | C29H24F3N5O | Molecular Weight | 515.53 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide;B-Raf IN 1 | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302 | Class | |
Precautionary Statements | P280-P305+P351+P338 | Packing Group |
Description
B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM). IC50 value: 24 nM (B-Raf); 25 nM (C-Raf) [1] Target: B-Raf/C-Raf inhibitor Compound 10n (B-Raf IN 1) was equipotent against c-Raf (IC50: 0.025 lM) Moderate selectivity was observed for compound 10n versus p38a (IC50: 0.216 lM) and CAMKII (IC50: 0.822 lM), while high selectivity was observed versus CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50s: >2 lM). |