For R&D use only.

8-bromo-1-octanol

  • Catalog NO.:A828309
  • CAS No. : 50816-19-8
  • Molecular Formula:C8H17BrO
  • Molecular Weight: 209.12
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Product Details

CAS Number 50816-19-8 Appearance Yellow solid
Catalog Number A828309 MDL Number MFCD00010388
Molecular Formula C8H17BrO Molecular Weight 209.12
Boiling Point 282.1°C at 760 mmHg Melting Point
Flash Point Density 1.22 g/mL at 25 °C(lit.)
Synonyms 8-bromooctan-1-ol
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315; H319; H335 Class
Precautionary Statements P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501 Packing Group

Description

PLX5562 is a highly selective brain-penetrant CSF1R inhibitor. In the 5xFAD mouse model of AD, plaques fail to form in the parenchymal space following microglial depletion, except in areas containing surviving microglia. Microglia appear to contribute to multiple facets of AD etiology – microglia appear crucial to the initial appearance and structure of plaques, and following plaque formation, promote a chronic inflammatory state modulating neuronal gene expression changes in response to Aβ/AD pathology. PLX5622 demonstrated desirable PK properties in mice, rats, dogs, and monkeys with a brain penetrance of ~20%.

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8-bromo-1-octanol
8-bromooctan-1-ol