For R&D use only.

4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline

  • Catalog NO.:A884617
  • CAS No. : 14544-47-9
  • Molecular Formula:C21H18N6
  • Molecular Weight: 354.41
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Quality Control&SDS
SDS COA NMR

Product Details

CAS Number 14544-47-9 Appearance Light yellow powder
Catalog Number A884617 MDL Number MFCD04116311
Molecular Formula C21H18N6 Molecular Weight 354.41
Boiling Point 380-382°C at 760 mmHg Melting Point
Flash Point Density
Synonyms 4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H301-H312-H315-H319-H373-H410 Class
Precautionary Statements P273-P280-P301+P310-P403+P233 Packing Group

Description

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

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4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline
4,4',4''-(1,3,5-Triazine-2,4,6-triyl)trianiline