5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine

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For R&D use only.

Catalog NO.：A848911
CAS No. : 588691-24-1
Molecular Formula：C₃₁H₃₁In₂O₈
Molecular Weight： 686.49

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Quality Control&SDS

SDS COA HPLC/GC NMR

Product Details

CAS Number	588691-24-1	Appearance	Off-white powder
Catalog Number	A848911	MDL Number	MFCD01631070
Molecular Formula	C₃₁H₃₁In₂O₈	Molecular Weight	686.49
Boiling Point		Melting Point
Flash Point		Density
Synonyms	5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302;H315;H319;H335	Class
Precautionary Statements	P261;P305+P351+P338	Packing Group

Description

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

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My Tracks: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-iodo-2'-O-methyl-uridine

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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