H-Glu(OtBu)-OMe.HCl

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For R&D use only.

Catalog NO.：A833723
CAS No. : 6234-01-1
Molecular Formula：C₁₀H₂₀ClNO₄
Molecular Weight： 253.72

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Product Details

CAS Number	6234-01-1	Appearance
Catalog Number	A833723	MDL Number	MFCD00153438
Molecular Formula	C₁₀H₂₀ClNO₄	Molecular Weight	253.72
Boiling Point		Melting Point	126-130°C
Flash Point		Density
Synonyms	5-tert-butyl 1-methyl (2S)-2-aminopentanedioate hydrochloride
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	Not hazmat
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

937263-43-9 (Arry-380)

937265-83-3 (ARRY-380 analog)

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