6H-Dibenzo[c,e][1,2]oxaphosphinine 6-oxide
- Catalog NO.:A823057
- CAS No. : 35948-25-5
- Molecular Formula:C12H9O2P
- Molecular Weight: 216.17
1. Please click the to confirm the discount and stock quantity.
2. Click“Bulk Inquiry”to ask for quotations of other quantity.
3. The price does not include shipping and bank charges.
Product Details
CAS Number | 35948-25-5 | Appearance | |
Catalog Number | A823057 | MDL Number | MFCD00040561 |
Molecular Formula | C12H9O2P | Molecular Weight | 216.17 |
Boiling Point | 399.7°C at 760 mmHg | Melting Point | 115-118°C |
Flash Point | Density | 1.402 | |
Synonyms | 6H-Dibenzo[c,e][1,2]oxaphosphinine 6-oxide | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H315; H319; H335 | Class | |
Precautionary Statements | P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501 | Packing Group |
Description
PLX5562 is a highly selective brain-penetrant CSF1R inhibitor. In the 5xFAD mouse model of AD, plaques fail to form in the parenchymal space following microglial depletion, except in areas containing surviving microglia. Microglia appear to contribute to multiple facets of AD etiology – microglia appear crucial to the initial appearance and structure of plaques, and following plaque formation, promote a chronic inflammatory state modulating neuronal gene expression changes in response to Aβ/AD pathology. PLX5622 demonstrated desirable PK properties in mice, rats, dogs, and monkeys with a brain penetrance of ~20%. |