2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide

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For R&D use only.

Catalog NO.：A853596
CAS No. : 55921-65-8
Molecular Formula：C₈H₁₃N₅O
Molecular Weight： 195.11

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Product Details

CAS Number	55921-65-8	Appearance	Off-white powder
Catalog Number	A853596	MDL Number	MFCD22041981
Molecular Formula	C₈H₁₃N₅O	Molecular Weight	195.11
Boiling Point		Melting Point	278℃ (DEC.)
Flash Point		Density
Synonyms	2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Danger	UN Number	3259
Hazard Statements	H314	Class	8
Precautionary Statements	P280-P305+P351+P338-P310	Packing Group	Ⅲ

Description

(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5.

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P401	Store …
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P501	Dispose of contents/container to..…
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
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H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
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