1,4,5,8-Naphthalenetetracarboxylic dianhydride

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For R&D use only.

Catalog NO.：A840089
CAS No. : 81-30-1
Molecular Formula：C₁₄H₄O₆
Molecular Weight： 268.18

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Product Details

CAS Number	81-30-1	Appearance
Catalog Number	A840089	MDL Number	MFCD00006915
Molecular Formula	C₁₄H₄O₆	Molecular Weight	268.18
Boiling Point	617°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	[2]Benzopyrano[6,5,4-def][2]benzopyran-1,3,6,8-tetrone
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

698387-09-6 (free base)

915942-22-2 (maleate)

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