Derazantinib
- Catalog NO.:A903432
- CAS No. : 1234356-69-4
- Molecular Formula:C29H29FN4O
- Molecular Weight: 468.57
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Product Details
CAS Number | 1234356-69-4 | Appearance | |
Catalog Number | A903432 | MDL Number | MFCD30532770 |
Molecular Formula | C29H29FN4O | Molecular Weight | 468.57 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | ARQ 087; ARQ087; AR-Q087;(6R)-6-(2-fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302-H315-H319-H335 | Class | |
Precautionary Statements | P261-P305+P351+P338 | Packing Group |
Description
Derazantinib, also known as ARQ-087, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival. |