SNX-2112

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For R&D use only.

Catalog NO.：A903360
CAS No. : 908112-43-6
Molecular Formula：C₂₃H₂₇F₃N₄O₃
Molecular Weight： 464.48

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Product Details

CAS Number	908112-43-6	Appearance
Catalog Number	A903360	MDL Number	MFCD16038907
Molecular Formula	C₂₃H₂₇F₃N₄O₃	Molecular Weight	464.48
Boiling Point	619.8±55.0°C at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	PF 04928473; PF-04928473; PF04928473;4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide;4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302	Class
Precautionary Statements	P280-P305+P351+P338	Packing Group

Description

SNX-2112, also known as PF 04928473, is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
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H300	Acute toxicity,oral (Category 1, 2)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
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H371	Specific target organ toxicity, single exposure (Category 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
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H420	Hazardous to the ozone layer (Category 1)