IT-901
- Catalog NO.:A903447
- CAS No. : 1584121-99-2
- Molecular Formula:C17H14N2O4S
- Molecular Weight: 342.37
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Product Details
CAS Number | 1584121-99-2 | Appearance | |
Catalog Number | A903447 | MDL Number | |
Molecular Formula | C17H14N2O4S | Molecular Weight | 342.37 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H302;H315;H319;H335 | Class | |
Precautionary Statements | P261;P305+P351+P338 | Packing Group |
Description
IT-901 is a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses. IT-901 potently inhibits the NF-κB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-κB-dependent lymphoma. IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. IT-901 is a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease. |