Oritavancin diphosphate
- Catalog NO.:A900914
- CAS No. : 192564-14-0
- Molecular Formula:C86H103Cl3N10O34P2
- Molecular Weight: 1790.56
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Product Details
CAS Number | 192564-14-0 | Appearance | |
Catalog Number | A900914 | MDL Number | |
Molecular Formula | C86H103Cl3N10O34P2 | Molecular Weight | 1790.56 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | LY333328; LY-333328; LY 333328; Oritavancin; Oritavancin diphosphate;(4R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-α-L-arabinohexopyranosyl)-N3-(p-(p-chlorophenyl)benzyl)vancomycin diphosphate | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | UN Number | ||
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Precautionary Statements | Packing Group |
Description
Oritavancin, also known as LY333328, is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci. Oritavancin was more active than either metronidazole or vancomycin against strains of Clostridium difficile tested. Oritavancin has potential use as a therapy for exposure to Bacillus anthracis, the Gram-positive bacterium that causes anthrax, having demonstrated efficacy in a mouse model both before and after exposure to the bacterium. The 4'-chlorobiphenylmethyl group disrupts the cell membrane of Gram-positive bacteria. It also acts by inhibition of transglycosylation and inhibition of transpeptidation. 192564-14-0 (diphosphate salt); 171099-57-3 (free base) |