2-Chloro-7-methoxyquinoline-3-carbonitrile

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For R&D use only.

Catalog NO.：A849248
CAS No. : 128259-63-2
Molecular Formula：C₁₁H₇ClN₂O
Molecular Weight： 218.63908

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Product Details

CAS Number	128259-63-2	Appearance
Catalog Number	A849248	MDL Number	MFCD02232018
Molecular Formula	C₁₁H₇ClN₂O	Molecular Weight	218.63908
Boiling Point		Melting Point	195-196°C
Flash Point		Density
Synonyms	2-Chloro-7-methoxy-quinoline-3-carbonitrile
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number	UN2811
Hazard Statements	H315; H319; H335	Class	6.1
Precautionary Statements	P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501	Packing Group	III

Description

Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.

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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
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H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
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H311	Acute toxicity,dermal (Category 3)
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H318	Serious eye damage/eye irritation (Category 1)
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H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
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H340	Germ cell mutagenicity (Category 1A, 1B)
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H361	Reproductive toxicity (Category 2)
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H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
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