(S)-PMPA

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Catalog NO.：A884457
CAS No. : 147127-19-3
Molecular Formula：C₉H₁₄N₅O₄P
Molecular Weight： 287.21

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	147127-19-3	Appearance	White powder
Catalog Number	A884457	MDL Number	MFCD21604708
Molecular Formula	C₉H₁₄N₅O₄P	Molecular Weight	287.21
Boiling Point	616.1°C at 760 mmHg	Melting Point	>260°C
Flash Point		Density	1.79
Synonyms	(S)-Tenofovir;(S)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H315-H317-H319-H335	Class
Precautionary Statements	P261-P280-P305+P351+P338	Packing Group

Description

LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
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H330	Acute toxicity,inhalation (Category 1, 2)
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