Gilteritinib

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For R&D use only.

Catalog NO.：A901674
CAS No. : 1254053-43-4
Molecular Formula：C₂₉H₄₄N₈O₃
Molecular Weight： 552.71

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Quality Control&SDS

SDS COA NMR

Product Details

CAS Number	1254053-43-4	Appearance	Light yellow powder
Catalog Number	A901674	MDL Number	MFCD28144685
Molecular Formula	C₂₉H₄₄N₈O₃	Molecular Weight	552.71
Boiling Point		Melting Point
Flash Point		Density
Synonyms	6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

Tirabrutinib HCl, also known as ONO-4059 HCl, is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. As a result, this agent may inhibit the proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

1439901-97-9 (ONO-4059 HCl)

1351636-18-4 (ONO-4059 free base)

1351635-67-0 (ONO-4059 analog)

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H200	Explosives (Unstable Explosive)
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