3-Chloro-2-fluorobenzaldehyde
- Catalog NO.:A21250
- CAS No. : 85070-48-0
- Molecular Formula:C7H4ClFO
- Molecular Weight: 158.56
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Product Details
CAS Number | 85070-48-0 | Appearance | Light yellow liquid or crystallize |
Catalog Number | A21250 | MDL Number | MFCD01631571 |
Molecular Formula | C7H4ClFO | Molecular Weight | 158.56 |
Boiling Point | 214 °C(lit.) | Melting Point | 26-27°C |
Flash Point | 186 °F | Density | 1.35 |
Synonyms | 3-Chloro-2-fluoro-benzaldehyde | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | Not hazmat |
Hazard Statements | H227; H315; H319; H335 | Class | |
Precautionary Statements | P210; P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P370+P378; P403+P233; P403+P235; P405; P501 | Packing Group |
Description
Ruxolitinib, also known as INC424 and INCB18424 or INCB018424, is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. |