For R&D use only.

Ir[dF(Me)ppy]2(dtbbpy)PF6

  • Catalog NO.:A904034
  • CAS No. : 1335047-34-1
  • Molecular Formula:C42H40F10IrN4P
  • Molecular Weight: 1013.97
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Product Details

CAS Number 1335047-34-1 Appearance
Catalog Number A904034 MDL Number MFCD31619196
Molecular Formula C42H40F10IrN4P Molecular Weight 1013.97
Boiling Point Melting Point
Flash Point Density
Synonyms Iridium(III) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate
Storage Condition Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word Warning UN Number
Hazard Statements H315-H319-H335 Class
Precautionary Statements P261-P305+P351+P338 Packing Group

Description

AMD11070, also known as AMD070, X4P-001 and mavorixafor, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas.

558447-26-0 (free)

880549-30-4 (HCl)

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Ir[dF(Me)ppy]2(dtbbpy)PF6
Iridium(III) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate