5-Bromo-3-methyl-1-phenyl-1H-pyrazole

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For R&D use only.

Catalog NO.：A6848
CAS No. : 41327-15-5
Molecular Formula：C₁₀H₉BrN₂
Molecular Weight： 237.10

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Product Details

CAS Number	41327-15-5	Appearance
Catalog Number	A6848	MDL Number	MFCD00462191
Molecular Formula	C₁₀H₉BrN₂	Molecular Weight	237.10
Boiling Point	312.5℃ at 760 mmHg	Melting Point
Flash Point		Density
Synonyms	5-Bromo-3-methyl-1-phenyl-1H-pyrazole
Storage Condition	Store in a tightly closed container,in a cool and dry place

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Description

Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Palbociclib, was approved on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer.

571190-30-2 (free base)

827022-32-2 (HCl)

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